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KMID : 0351219950270030261
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Korean Journal of Infectious Diseases
1995 Volume.27 No. 3 p.261 ~ p.266
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Therapeutic Efficacy of Ciclopirox Nail Lacquer in the Treatment of Onychomycosis
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김병수
박경찬/김정애/방형돈/조광현/윤재일
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Abstract
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Background:
@EN Topical antifungal agents have been ineffective in the treatment of onychomycosis because they could not reach the infected nail bed. 8% ciclopirox nail lacquer is a new topical antimycotic which is characterzed by excellent penetration into
the
nail plate. We performed a study to assess the therapeutic efficacy and safety of 8% ciclopirox nail lacquer in the treatment of onychomycosis.
@ES Methods:
@EN We assessed 27 onychomycotic patients whose affected area of target nail plate was not more than 50%. The patients were instructed to apply 8% ciclopirox nail lacquer once daily and evaluated monthly for 6 months. Mycological examinations
were
done
before and after the treatment. Overall efficacy, tolerability, cosmetic acceptance and adverse effects were assessed at the end of 6 months' treatment.
@ES Results:
@EN: The mean percentage of affected area decreased from 28.9% to 4.7%. Mycological cure rate was 77.8% at the end of the treatment. Overall efficacy assessed by physician and patients were similar and evaluated as complete cure in 48% and 44%,
respectively. Tolerability and cosmetic acceptance were excellent or good in most of the patients. No systemic adverse effects were found, but 3 patients complained of mild prickling sensation of ingrowing toe nail.
@ES Conclusions:
@EN These data suggest that 8% ciclopirox nail lacquer is safe and effective in the treatment of mild onychomycosis
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KEYWORD
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